Science Says!
N-170
Welcome to Issue 170 of Science Says! Our weekly newsletter where you’ll learn the latest healthy aging and C15:0 research news that our team of doctors, scientists, and experts are most excited about—without having to go search for it.
Eric and Steph
Co-Founders, Doctors, Nerds
What Dr. Stephanie Venn-Watson, our co-founder and author of The Longevity Nutrient and over 80 peer-reviewed scientific publications, is reading.
A research team in Rennes, France went to the grocery store, filled their baskets, and then measured how much C15:0 was in each of the food items. In addition to testing an impressive 15 different types of cheeses (this was France), they also measured C15:0 in other dairy products, as well as a variety of meats, fish & fish oils, seeds & seed oils, fruits & vegetables, and fermented products. Let’s see what they found (and what you may want in your grocery basket to optimize your C15:0 levels).
Sounds fun. Which foods had the most C15:0?
Not surprisingly, butter and cheese ruled over everything else in the grocery basket. Of the cheeses, the following had the highest C15:0 (measured as a % of total fatty acids):
Now you know what to put on your next cheese plate. Interestingly, most of the full-fat dairy products – be it butter, yogurt, or cheese, had around 1.5% of C15:0, which is higher than what has been reported in dairy products outside of France. Full-fat dairy products in the U.S. typically have around 1.0% C15:0.
Proportion of fatty acids vs. absolute amounts in full-fat dairy foods
In this study, Ciesielski et al. measured both the % of C15:0 among all fatty acids and the actual concentration of C15:0 in food (reported as mg per 100 g product). While most full-fat dairy products had around 1.5% of C15:0 among all fatty acids, the wheat was truly separated from the chaff (or the butter from the yogurt) when they compared the actual amount of C15:0 per 100 grams of product.
In their study, they showed that butter had – by far – the highest amount of C15:0 per 100 grams. This was followed by cheese… and then yogurt (don’t even bother with the stirred yogurts).
What else, besides full-fat dairy products, had C15:0?
Aside from full-fat dairy products, there were some types of fish and fish oils that had mentionable C15:0.
Among fish, most types – like cod, tuna, and haddock – only had 1 mg per 100 g of fish. A couple of winning fish types, however, included salmon (26 mg/100 g) and mackerel (53 mg/100 g). For reference, 100 g of fish is about a single serving size. When it came to fish oils, menhaden oil had an impressive 852 mg/100 g oil and mullet oil had 873 mg/100 g oil. Keep in mind, however, that 100 g of fish oil is equivalent to about a half cup of oil.
So, what are the optimal grocery basket items when it comes to C15:0?
Based on this study, here’s a sample grocery check list to boost your C15:0 (at least in France):
Yum. Alas, veggies, fruits, and tofu had negligible C15:0.
So, Where Do C15:0 Supplements Come In?
Studies have repeatedly shown that people need between 100 to 200 mg of added C15:0 per day to achieve healthy C15:0 levels (around 0.2% or 20 µM). So, if we can find foods that can deliver 100 to 200 mg of needed dietary C15:0 per day, then why supplement with C15:0?
Well, C15:0 supplementation is intended to achieve two objectives:
Achieve and maintain healthy C15:0 levels (> 0.2% or 20 µM): People who avoid full-fat dairy have lower C15:0 levels. Klein et al. showed that vegans had average C15:0 levels that were half of non-vegans (0.1%). C15:0 supplementation (100 to 200 mg/day) can help people who avoid dairy fat to maintain healthy C15:0 levels.
Optimize C15:0 levels (0.3-0.6%, or > 30 uM): For those of us who do indulge in full-fat dairy products, C15:0 supplementation can help people reach higher C15:0 levels that have been associated with:
It can be difficult to reliably maintain and achieve these optimal levels using dairy fat alone, keeping in mind that dairy fat also has much higher levels (about 40%) of pro-inflammatory even-chain saturated fats. In fact, both Schaefer et al. and Shi et al. showed that higher levels of total saturated fats and even-chain pro-inflammatory fats (like C16:0) in dairy fat are associated with a higher risk of developing type 2 diabetes and cardiovascular disease.
That’s where a pure C15:0 supplement comes in – to get the good C15:0 without the bad fats. With that, have a fantastic & (high quality) cheesy week, everyone!
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