Pure C15:0 went head-to-head against leading longevity drugs… and won.

Healthy Aging

The ultimate healthy aging molecule

This past week, we had our latest big science drop, which was published in the peer-reviewed scientific journal, Nutrients. So, let’s get to it.

A new C15:0 discovery? Do tell.

Well, given the voluminous science supporting the broad long-term health benefits of C15:0 (pentadecanoic acid), we decided to raise the science bar WAY up.

We had previously demonstrated that C15:0 has 3x more cellular benefits than the purest, highest performing omega-3 (EPA). So, why not see how C15:0 does against three top contenders to extend human longevity: rapamycin, metformin, and acarbose?

Here’s what we found.
In this study, pure C15:0 had the most cell repairing benefits (n=36 benefits), closely followed by rapamycin (n=32 benefits), then metformin (n=17 benefits). Acarbose came in last, with 5 cell-based activities. Our results showed that C15:0 is an essential nutrient with cellular benefits that match, and even surpass, leading longevity-enhancing compounds.

This sounds good. But what do you mean by “cell repairing benefits”?

Glad you asked. This study used an industry standard set of human cell-based assays called BioMAP Diversity PLUS. BioMAP, which is conducted by independent, third-party experts, includes twelve different cell systems representing a wide variety of conditions mimicking various chronic disease states.

These cell systems were treated with each of our four test compounds at four doses. An impressive 148 biomarkers were measured to see: 1) what cell repairing benefits, if any, does the compound have in the various cell systems compared to non-treated controls, 2) if these benefits are dose-dependent, and 3) if the compound can repair cells safely.

This is how we know that C15:0 had 36 significant, dose-dependent benefits across 10 of the 12 human cell systems. All while being safe to our cells, too.

Great. How are these benefits relevant to longevity?

Pure C15:0 did a bunch of good things that are expected to extend both our healthspan and lifespan, including:

• Taming numerous pro-inflammatory cytokines and chemokines
• Stopping bad “zombie” cells from proliferating
• Slowing tissue scarring, including in systems relevant to heart, lung, and liver health

At their optimal, highest performing doses, C15:0 (17 uM) and rapamycin (9 uM) share a remarkable 24 cell-repairing benefits. This is even more remarkable, given that pure C15:0 is a natural and safe essential fatty acid, while rapamycin is a prescription drug borne from rare bacteria that grow on Easter Island. I’ll take C15:0, please.