Repairing & Restoring Cellular Health

C15:0 works at the cellular level to reverse key hallmarks of aging, while reducing clinically-relevant drivers of chronic disease.

Mechanism

The essentiality of C15:0 is borne from numerous cellular benefits

C15:0 is a pleiotropic nutrient, which means that it acts in multiple ways to provide broad physical and mental health benefits. Specifically, C15:0 works by naturally targeting key receptors, reversing hallmarks of aging, lowering drivers of chronic disease, and making a beneficial metabolite. Please Note: All peer-reviewed studies demonstrating the active benefits of C15:0 used pure, free fatty acid C15:0 powder at appropriate concentrations. These benefits are not expected from products that combine C15:0 with oils or competing proinflammatory fatty acids.

Targeted Receptors

Targeted Receptors

By naturally targeting receptors throughout out bodies, C15:0 has been shown to:

  • Activate the AMPK pathway which maintains cellular homeostasis, regulates glucose metabolism, and is a core component of the human longevity pathway.
  • Activate PPAR alpha-delta receptors that regulate metabolism, immunity, mood, appetite, and sleep.
  • Inhibit HDAC-6, which reduces cancer cell proliferation.
  • Inhibit MAPK and JAK-STAT signaling, which reduces inflammation.

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Reversed Hallmarks of Aging

Reversed Hallmarks of Aging

C15:0 reverses multiple drivers of aging and has been shown to:

  • Improve cellular resilience against premature breakdown.
  • Decrease reactive oxygen species and lipid peroxidation.
  • Repair mitochondrial function and increase ATP production.
  • Improve cellular signaling.
  • Slow a key biomarker of aging rate (i.e. raise hemoglobin).

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Lowered Drivers of Chronic Disease

Lowered Drivers of Chronic Disease

C15:0 has been shown to lower clinically-relevant biomarkers of chronic disease, including:

  • Lower proinflammatory cytokines, including IL-6, MCP-1, VCAM-1, and PAI-1.
  • Decrease proliferation of cancer cells.
  • Decrease proliferation of fibroblasts to help slow or stop tissue fibrosis.
  • Increase glucose uptake by cells.
  • Treat multiple human cell disease systems mimicking inflammation, cardiovascular disease, liver cirrhosis, autoimmune disease, and allergies.

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Produced Active Metabolites

Produced Active Metabolites

Our bodies use C15:0 to make a metabolite called pentadecanoylcarnitine (or PDC), which has been shown to:

  • Activate CB1 and CB2 receptors that regulate mood, sleep, inflammation, and pain.
  • Activate 5-HT1A and 5-HT1B receptors that help to lower stress.
  • Inhibit H1 and H2 histamine receptors, which helps to treat allergy symptoms.

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Whole Body Health & Wellness

A strong body of science shows that C15:0 promotes cardiometabolic, immune and liver health, while a key C15:0 metabolite can support mental and cognitive health.

Whole Body  Health & Wellness